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Huang KC, Yang CC, Hsu SP, Lee KT, Liu HW, Morisawa S, Otsubo K, Chien CT.
Department of Family Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan. Department of Family Medicine, Ulusal Tayvan Üniversitesi Tıp Koleji ve Ulusal Tayvan Üniversitesi Hastanesi, Taipei, Tayvan of.
Chronic hemodialysis (HD) patients increase erythrocyte susceptibility to hemolysis and impair cell survival. Kronik hemodiyaliz (HD) patients Hemolysis için eritrosit duyarlılık artışı ve hücre yaşam azaltabilir. We explored whether electrolyte-reduced water (ERW) could palliate HD-evoked erythrocyte impairment and anemia. Edip elektrolit-azaltılmış su (ERW) HD mazur olabilir eritrosit bozulması ve anemi evoked araştırılmalıdır. Forty-three patients undergoing chronic HD were enrolled and received ERW administration for 6 month. Kırk üç hasta kronik HD geçiyor kayıtlı ve 6 ay için ERW yönetimi aldı. We evaluated oxidative stress in blood and plasma, erythrocyte methemoglobin (metHb)/ferricyanide reductase activity, plasma metHb, and proinflammatory cytokines in the chronic HD patients without treatment (n=15) or with vitamin C (VC)- (n=15), vitamin E (VE)-coated dialyzer (n=15), or ERW treatment (n=15) during an HD course. Biz kan ve plazma, eritrosit methemoglobin (metHb) / ferricyanide redüktaz aktivite, plazma metHb ve proinflammatory cytokines kronik HD hastalarda tedavi (n = 15) veya C vitamini (VC) ile - (n = 15) olmadan oksidatif stres değerlendirilecektir , E vitamini (VE)-bir HD sırasında dialyzer (n = 15) veya ERW tedavi (n = 15) kaplı. The patients showed marked increases (15-fold) in blood reactive oxygen species, mostly H(2)O(2), after HD without any treatment. The patients, HD sonra tedavi ile artar (15 kat) kandaki reaktif oksijen türleri, çoğunlukla H (2) O (2) işaretli gösterdi. HD resulted in decreased plasma VC, total antioxidant status, and erythrocyte metHb/ferricyanide reductase activity and increased erythrocyte levels of phosphatidylcholine hydroperoxide (PCOOH) and plasma metHb. HD azalarak plazma VC, toplam antioksidan durumu ve eritrosit metHb sonuçlandı / ferricyanide redüktaz aktivitesi ve phosphatidylcholine hydroperoxide (PCOOH) ve plazma metHb ve eritrosit düzeyleri artmıştır. Antioxidants treatment significantly palliated single HD course-induced oxidative stress, plasma and RBC PCOOH, and plasma metHb levels, and preserved erythrocyte metHb /ferricyanide reductase activity in an order VC>ERW>VE-coated dialyzer. Antioksidanlar tedavisinde önemli ve plazma metHb düzeyleri, oksidatif stres, plazma ve RBC PCOOH tek HD ders endüksiyonlu palliated ve sipariş VC yılında> ERW> VE kaplı dialyzer eritrosit metHb / ferricyanide redüktaz etkinliği korunmuş. However, ERW had no side effects of oxalate accumulation easily induced by VC. Ancak, ERW oksalat birikimi hiçbir yan etkisi kolayca VC ile indüklenen vardı. Six-month ERW treatment increased hematocrit and attenuated proinflammatory cytokines profile in the HD patients. Altı aylık ERW tedavi HD hastalarda hematokrit ve attenuated proinflammatory cytokines profil arttı. In conclusion, ERW treatment administration is effective in palliating HD-evoked oxidative stress, as indicated by lipid peroxidation, hemolysis, and overexpression of proinflammatory cytokines in HD patients. Sonuç olarak, ERW tedavi yönetimi HD palliating etkili olduğunu-evoked oksidatif stres, lipid peroksidasyonu olarak, Hemolysis gösterilir, ve HD hastalarda proinflammatory cytokines ve overexpression.
PMID: 16760903 [PubMed - indexed for MEDLINE] PMID: 16760903 [PubMed - MEDLINE için dizine]
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